The overall objective of the INCEPT research programme is to develop a framework to test many interventions used in intensive care units (ICU) to the benefit of the sickest patients in the hospital, their relatives, and society.

The programme aims to prepare, initiate, and run an adaptive platform trial assessing commonly used interventions in adult critically ill patients acutely admitted to (initially) Danish ICUs. 

A platform trial focuses on a disease or a setting; thus, the overarching design does not focus on a single intervention. By building a platform trial, we can continuously enroll many ICU patients in Denmark and randomly allocate them to multiple interventions nested in different domains.

The platform trial contains five overarching frameworks:

• The ethical and legal framework
• The methodological framework
• The funding framework
• The data framework
• The initial assessment of intervention