Original articles

3. Granholm A, Kaas-Hansen BS, Lange T, et al. An overview of methodological considerations regarding adaptive stopping, arm dropping and randomisation in clinical trials. J Clin Epidemiol 2022; 10.1016/j.jclinepi.2022.11.002. doi:10.1016/j.jclinepi.2022.11.002

2. Granholm A, Anthon CT, Kjær MN, et al. Patient-Important Outcomes Other Than Mortality in Contemporary ICU Trials: A Scoping Review. Crit Care Med 2022; 10.1097/CCM.0000000000005637. doi:10.1097/CCM.0000000000005637

1. Granholm A, Jensen AKG, Lange T, Kaas-Hansen BS. adaptr: an R package for simulating and comparing adaptive clinical trials. J Open Source Softw. 2022;7:4284. doi:10.21105/joss.04284


1. Granholm A (author, mantainer), Kaas-Hasen BS (author), Jensen AKG (contributor), Lange T (contributor). adaptr: Adaptive Trial Simulator [R package]. 2022. GitHub: https://github.com/INCEPTdk/adaptr. CRAN: https://cran.r-project.org/package=adaptr. Website/manual: https://inceptdk.github.io/adaptr/.


Protocols published as full-text journal articles:

5. Kaas-Hansen BS, Granholm A, Anthon CT, Kjær MN, Sivapalan P, Maagaard M, Schjørring OL, Fagerberg SK, Ellekjær KL, Mølgaard J, Ekstrøm CT, Møller MH, Perner A. Causal inference for planning randomised critical care trials: protocol for a scoping review. Acta Anaesthesiol Scand. 2022; Epub 20 Aug 2022. doi:10.1111/aas.14142

4. Kjær MN, Granholm A, Vesterlund GK, et al. Development of a core outcome set for general intensive care unit patients-A protocol. Acta Anaesthesiol Scand. 2021;66:415-424. doi:10.1111/aas.14024

3. Granholm A, Schjørring OL, Jensen AKG, et al. Health-related quality of life and days alive without life support or out of hospital: Protocol. Acta Anaesthesiol Scand. 2022;66:295-301. doi:10.1111/aas.14001

2. Barot E, Kjær MN, Collet M, et al. Patient and public involvement in contemporary large intensive care trials: Protocol for a meta-epidemiological study. Acta Anaesthesiol Scand. 2021;65:1351-1354. doi:10.1111/aas.13953

1. Granholm A, Kaas-Hansen BS, Kjær MN, et al. Patient-important outcomes other than mortality in recent ICU trials: Protocol for a scoping review. Acta Anaesthesiol Scand. 2021;65:1002-1007. doi:10.1111/aas.13937

Protocols publicly registered:

1. Granholm A, Lange T, Harhay MO, Perner A, Møller MH, Kaas-Hansen BS. Effects of regularising, sceptical priors on the performance of adaptive clinical trials. OSF Registries. 2022. doi:10.17605/OSF.IO/U56XM


1. Kjær MN, Granholm A, Perner A, Collet MO. Development of a core outcome set for general intensive care unit patients-Need for a broader context-Author’s reply. Acta Anaesthesiol Scand. 2022;66:541-542. doi:10.1111/aas.14030